Publications

Check out these publications for relevant stories in Medicinal Chemistry and CMC. For a complete list of publications and patents, visit Google Scholar.

Medicinal Chemistry

CMC

Shi, S.; Zhao, H.; Mao, J.; Li, X.; Wang, W.; Ichikawa, Y.; Clark, R. B. Synthetic processes and intermediates for preparing therapeutic azaketolides. Patent Application No. WO 2024/036254 A2.

Ronn, M.; Zhu, Z.; Hogan, P. C.; Zhang, W.-Y.; Niu, J.; Katz, C. E.; Dunwoody, N.; Gilicky, O.; Deng, Y.; Hunt, D. K.; He, M.; Chen, C.-L.; Sun, C.; Clark, R. B.; Xiao, X.-Y. Process R&D of Eravacycline: The First Fully Synthetic Fluorocycline in Clinical Development. Org. Process Res. Dev. 2013, 17, 838-845. https://doi.org/10.1021/op4000219

Clark, R. B.; Elbaum, D. An orthogonal protection strategy for the synthesis of 2-substituted piperazines. Tetrahedron 2007, 63, 3057-3065. https://doi.org/10.1016/j.tet.2007.01.044

Graf, M. R.; Apte, S.; Terzo, E.; Padhye, S.; Shi, S.; Cox, M.; Clark, R. B.; Modur, V.; Badarinarayana, V. Novel Read through Agent: ZKN-0013 Demonstrates Efficacy in APCmin Model of Familial Adenomatous Polyposis. J. Mol. Med. 2023.

https://doi.org/10.1007/s00109-023-02291-x.

Myers, A. G.; Clark, R. B. Discovery of Macrolide Antibiotics Effective Against Multidrug-Resistant Gram-Negative Pathogens. Accounts of Chemical Research 2021, 54, 1635-1645. https://doi.org/10.1021/acs.accounts.1c00020

Clark, R. B.; Lamppu, D.; Libertine, L.; McDonough, A.; Kumar, A.; LaRosa, G.; Rush, R.; Elbaum, D. Discovery of Novel 2-​((Pyridin-​3-​yloxy)​methyl)​piperazines as α7 Nicotinic Acetylcholine Receptor Modulators for the Treatment of Inflammatory Disorders. J. Med. Chem. 2014, 57, 3966-3983. https://doi.org/10.1021/jm5004599

van Maanen, M. A.; Koopman, F. A.; Tak, P. P.; Papke, R. L.; Koepke, J.; Bevaart, L.; Vervoordeldonk, M. J.; Clark, R.; Lamppu, D.; LaRosa, G. J.; Elbaum, D. Two Novel α7 Nicotinic Acetylcholine Receptor Ligands: In Vitro Properties and Their Efficacy in Collagen-​Induced Arthritis in Mice. PLoS One. 2015, 10, e0116227. https://doi.org/10.1371/journal.pone.0116227

Clark, R. B.; He, M.; Deng, Y.; Sun, C.; Chen, C.-L.; Hunt, D. K.; O’Brien, W. J.; Fyfe, C.; Grossman, T. H.; Sutcliffe, J. A.; Achorn, C.; Hogan, P. C.; Katz, C. E.; Niu, J.; Zhang, W.-Y.; Zhu, Z.; Ronn, M.; Xiao, X.-Y. Synthesis and Biological Evaluation of 8-Aminomethyltetracycline Derivatives as Novel Antibacterial Agents. J. Med. Chem. 2013, 56, 8112-8138. https://doi.org/10.1021/jm401211t

Xiao, X.-Y.; Hunt, D. K.; Zhou, J.; Clark, R. B.; Dunwoody, N.; Fyfe, C.; Grossman, T. H.; O’Brien, W. J.; Plamondon, L.; Ronn, M.; Sun, C.; Zhang, W.-Y.; Sutcliffe, J. A. Fluorocyclines. 1. 7-Fluoro-9-pyrrolidinoacetamido-6-demethyl-6-deoxytetracycline: a Potent, Broad Spectrum Antibacterial Agent. J. Med. Chem. 2012, 55, 597-605. https://doi.org/10.1021/jm201465w

Clark, R. B.; Hunt, D. K.; He, M.; Achorn, C.; Chen, C.-L.; Deng, Y.; Fyfe, C.; Grossman, T. H.; Hogan, P.; O'Brien, W. J.; Plamondon, L.; Ronn, M.; Sutcliffe, J. A.; Zhu, Z.; Xiao, X.-Y. Fluorocyclines. 2. Optimization of the C-9 Side-Chain for Antibacterial Activity and Oral Efficacy. J. Med. Chem. 2012, 55, 606-622. https://doi.org/10.1021/jm201467r

25

Years Pharma and Biotech Experience

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Patents and Publications

6

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